Endocrine Abstracts

Objectives: The physiological role of prolactin in male sexual function has not been completely clarified. Aim of this study is the assessment of clinical features and of conditions associated with hyperprolactinemia in male patients consulting for sexual dysfunction.Design and methods: A consecutive series of 2146 (mean age 52.2±12.8 years) male patients with sexual dysfunction was studied. Several hormonal and biochemical parameters were studied a...

Context: Lipodystrophic HIV patients frequently display impaired pituitary GH response. Objective. To investigate the GH response to GHRH+Arg in women with HIV-related lipodystrophy (HARS) compared with healthy females. To identify possible predictive factors for such a GH response in these patients.Patients: Forty-nine female patients with HARS were compared with 10 healthy women matched for age and BMI.Methods: Patients and contr...

Objectives: Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are characterized by insulin resistance and often associated with male hypogonadism. To discriminate the specific contribution of T2DM and MetS to male hypogonadism.Design and methods: A consecutive series of 1134 (mean age 52.1±13 years) male patients with sexual dysfunction was studied. Several hormonal and biochemical parameters were studied along with ANDROTEST, a 12-item ...

Subjects and methods: We performed nocturnal penile tumescence and rigidity monitoring (NPTRM) in order to study the effects of Tadalafil on sleep-related erections in 23 adult healthy men (age: 34.27±8.48 years). The subjects were randomly administered Tadalafil, 10 mg tablet, the 1st (N1) or the 2nd (N2) night (Group A and B respectively) of 3 consecutive nights of erections’ monitoring. In Group A the 3rd night monitoring was regarded as control (N-ctr); in Group ...

A strong evidence suggests the role of BRAFV600E mutation in determining the aggressiveness of thyroid cancer. To detect how the association of BRAF mutation could influence the aggressiveness of particular subtypes of thyroid tumors, we analysed a possible correlation between BRAFV600E and metalloproteinase (MMPs) activity, as its enhanced production could be an important determinant of tumor invasion. For this purpose, we investigated the activity and t...

Objectives: The aim of present study was to verify possible differences in the prevalence of vasculogenic ED and hypogonadism comparing two distinct new definitions of MetS, as National Cholesterol Education Program-Third Adult Treatment Panel (NCEP-ATPIII) and International diabetes Federation (IDF) in patients with sexual dysfunction.Methods: Several hormonal, biochemical and instrumental (penile doppler ultrasound) parameters were studied. ANDROTEST S...

Objectives: Detecting hypogonadism is crucial in patients with sexual dysfunctions because hypogonadism can have a causal role for them and testosterone (T) substitution represents a milestone for the therapy. At present, three different inventories have been developed for screening of hypogonadism in aging male. All these instruments demonstrated a good sensitivity but low specificity. No inventories are available for the screening of hypogonadism in patients with sexual dysf...

Objectives: To date it is not clear to which extent a clinical, or even a subclinical, sexual dysfunction in the female partner might associate with erectile dysfunction (ED) in the male partner. The present study is aimed at the assessment of clinical features of ED associated with relational disturbances.Methods: In a consecutive series of 1140 male subjects reporting a stable couple relationship we evaluated the impact of relational factors, as assess...

Varicocele is a state of varicosity and tortuosity of the pampiniform plexus around the testis caused by retrograde blood flow. The association between varicocele and male subfertility has been questioned, thus the usefulness of treating varicocele in order to improve fertility is still a matter of debate. Inhibin B levels reflect the functional state of the seminiferous epithelium, and have been found to be a sensitive index of spermatogenesis. Serum inhibin B levels have bee...

Background: Serum thyroglobulin (Tg) is a useful marker of recurrent or persistent disease in the follow-up of patients with differentiated thyroid carcinoma (DTC); the presence of interfering Tg antibodies (TgAb), even in low concentrations, can lead to a distorted evaluation of this marker. However, TgAb by itself has been shown to be a marker of disease following surgery. TgAb recognition of Tg epitopes differs in pathological and non-pathological states and may thus have p...